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The tobacco was hoed for the first time about eight to ten days after planting, or to use a common expression, when the plants had "taken root." The tobacco was usually hoed once each week or as often as was deemed necessary to keep the soil "loose" and the weeds down

[237] Research [edit] Central nervous system [edit] While acute/initial nicotine intake causes activation of neuronal nicotinic receptors, chronic low doses of nicotine use leads to desensitization of those receptors (due to the development of tolerance) and results in an antidepressant effect, with early research showing low dose nicotine patches could be an effective treatment of major depressive disorder in non-smokers

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Today, not so much

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Ministry of Environmental Protection of the Peoples Republic of China