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The 1 -adrenoceptors are coupled to the Gq subfamily of G-proteins, the 2 -adrenoceptors are coupled to Gi subfamily, and the -adrenoceptors are coupled to Gs subfamily (Duman and Nestler, 2002)

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As tolerance increases, individuals often find themselves consuming larger amounts of nicotine, which further strengthens the addiction

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They make the quitting process more manageable and increase success rates

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