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since about 2007 and have grown into a $6.6 billion-a-year industry, are battery-powered devices that typically heat a flavored nicotine solution into an inhalable vapor

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In 1971, Philip Morris experimented on competitors brands and found that ammonia added at 0.25% concentration created a taste that was milder, more aromatic, sweeter, less harsh, and more like a Marlboro, whereas ammonia added at 0.50% concentration created an off taste.6 RJ Reynolds scientists later hypothesized that ammonia might improve tobacco smoke flavor by reacting with sugars to produce heterocyclic ring compounds known as pyrazines

[DOI] [PMC free article] [PubMed] [Google Scholar] 66.Wang H., Fan J., Yu C., Guo Y., Pei P., Yang L., Chen Y., Du H., Meng F., Chen J., et al

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