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The positive effects of nicotine include Leading health organisations have assessed the evidence and concluded that vaping is not risk-free but is far less harmful than smoking Update September 2022 A comprehensive (1,400 page) systematic review commissioned by England's Office for Health Improvement and Disparities concluded that This is because most of the harmful chemicals in smoke are absent from vapour

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For example, mutations in IDH1/2 lead to an increase in 2-HG, which competitively inhibits -ketoglutarate-dependent enzymes, such as ten-eleven translocation (TET) enzymes and histone demethylases