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Young JM et al (2001): Mecamylamine: new therapeutic uses and toxicity/risk profile

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Contradictory to the unaltered mitochondrial mass and reduced cristae number, however, ATP levels were increased in 10% CSE exposed cells by approximately 1.6 fold when compared to the control (0% CSE) condition (Figure 3B), which may reflect an increase in mitochondrial OXPHOS capacity

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This wasnt arbitraryit was based on substantial evidence of harm