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Nicotine binds to 42 and 7 nicotinic acetylcholine receptors (nAChRs) located on dopaminergic, glutamatergic and GABAergic neurons in the mesolimbic dopamine (DA) system, which causes an increase in extracellular DA in the nucleus accumbens (NAc)

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These changes in EV release dynamics were also associated with an increase in mean particle size at high concentrations, suggesting that these smoking-related stimuli may alter both the release and the characteristics of these BCEVs (Fig

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