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Varenicline works by binding to nicotine receptors in the body, partly turning them on to reduce withdrawal symptoms, but also blocking them from the nicotine in cigarettes and thus making smoking less pleasurable

The meta-analyses reported in the present study for each of the 36 health outcomes are based on evidence from a total of 793 studies published between 1970 and 2022 (Extended Data Fig

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4.2 Each item in the auction catalogue is listed with a description and an illustration