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When we compared the enzymatic activity of both purified recombinant proteins, we observed that GpoA Cys36Ala -His x6 lost the glutathione peroxidase capacity compared with GpoA wt -His x6 (Fig 4B)

J Virol 70(7):46834690 Guang C, Phillips RD, Jiang B, Milani F (2012) Three key proteasesangiotensin-I-converting enzyme (ACE), ACE2 and reninwithin and beyond the renin-angiotensin system

J., Federico, J., & Palacio, C

These undergo peroxidation through both enzymatic mechanisms (e.g., lipoxygenase) and non-enzymatic iron-catalyzed Fenton reactions, generating phospholipid hydroperoxides and toxic lipid radicals