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36 37 A smoker may feel the need to puff in order to attain threshold doses of nicotine and elicit the hedonic effects attributable to dopaminergic system reward pathways

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Between 2018 and 2019, the highest proportion of tobacco use initiation with IQOS among the IQOS users was 0.7 percent and it was observed in Italy, while the lowest proportion was 0.2 percent and it was detected in Germany