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Recent in vivo studies have used the rat model to examine genetic, cell morphological, and matrix remodeling changes in the IVD [14, 24, 25, 52]

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, nsp1 and nsp13 of SARS-CoV-2 could directly inhibit type I and II IFN signaling by blocking the phosphorylation of STAT1 and STAT2, indicating that there exist intimate and more complex cross-talks between the viral tropism and immune response [75, 76]

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