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A recent consensus report from the National Academies of Science, Engineering, and Medicine on the Public Health Consequences of E-cigarettes 7 showed moderate evidence that e-cigarettes increase coughing, wheezing as well as asthma exacerbation in adolescents

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Considerable heterogeneity across the epidemiologic research may represent the most plausible explanation of the controversial findings and make the results of meta-analyses less robust [11]