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However, in a study comparing the safety of 4 mg nicotine lozenges and 4 mg nicotine gums, it was found that the lozenges were similarly well tolerated as the gums and had no worsening effect on the patients with cardiovascular diseases (54)
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Cross-linked polyvinyl alcohol was used as a rate-controlling membrane in the patch and a zero-order controlled release system was obtained (87)
Harvard Dutta, Sanchari Sinha Dutta
