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These products are prevalent in many regions, particularly in South Asia, where they account for a significant portion of global consumption

Genetic variants in CYP3A4, CYP2C19, and GLP1R can predispose some patients to slower drug metabolism, heightened nausea sensitivity, or reduced medication efficacy

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They form during the curing and processing of tobacco and are found in both unburned tobacco and smoke

Toxic Effects: For accidental/intentional poisoning from nicotine/vaping, use T65.2 codes

Withdrawal-like rebound: If a dose is missed or the drug is stopped suddenly, pain and stiffness often surge back sharply