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A common challenge for real-time smoke analysis is the need to design a suitable smoke sampling interface, which takes into account the flow characteristics of a 2-s puff (during and interpuff)

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10.1152/physrev.00002.2020 11

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Significant early positive changes from baseline of a sensitive measure of obstruction in the more peripheral airways (i.e., forced expiratory flow measured between 25% and 75% of FVC) were already detected at 3 months after switching in those who completely gave up tobacco smoking, with steady progressive improvements being observed also at 6 and 12 months (Polosa R., unpublished observation)