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RETUNE follows the Trials within Cohorts (TwiCs) design 7

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The economic system of mercantilism, by which raw materials were shipped to England and finished products returned, depressed the production of cotton and rice partly because London merchants already had supply lines established elsewhere encouraging more farmers to devote their land to tobacco which remained in high demand

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Importantly, this framework includes our commitment to promoting and encouraging transparent research on nicotine science, separating the effects of nicotine alone from the harmful act of smoking and advancing scientific understanding of harm reduction