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Of note, several studies including ours 12,34 have documented even though cotinine can be served as the best available biomarker reflecting recent exposure to tobacco smoke, cotinine could only be considered as a proxy for long-term (or cumulative) tobacco smoke exposure

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"We now know that Indigenous peoples in the Americas have been using tobacco for much of time since they arrived," says study author Daron Duke, an archeologist at Far Western Anthropological Research Group in Nevada, to Inverse's Tara Yarlagadda

And in many countries, a majority of these smokers are men