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Inversely, Bifidobacteriaceae are decreased in gut microbiota of Nlrp6 -/- mice whereas increased in the fecal microbiome of COPD patients ( In addition, severe COPD was associated with reduced sputum microbiota diversity ( -/- mice could interfere with host defense against lung infection, in particular triggered by Streptococcus pneumonia ( S.p .) and frequently associated with COPD exacerbation ( S.p ( -/- mice ( Statements Data availability statement The original contributions presented in the study are publicly available

To ensure that the coding framework was both theoretically informed and grounded in the data, the research team engaged in a collaborative immersion process