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[DOI] [PubMed] [Google Scholar] 111.Petrache I., Natarajan V., Zhen L., Medler T.R., Richter A.T., Cho C., Hubbard W.C., Berdyshev E.V., Tuder R.M

The research doesnt give a physiological explanation for the results, but Silverstein says that since nicotine and smoking harm the vascular system, the findings suggest they also damage blood vessels and neurons in the retina

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Nicotine stains appear as an unsightly dirty yellow-brown colour that goes beyond simple surface dirt