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For patients in whom cisplatin cannot be used, carboplatin can be substituted but non-randomised data have shown lower response rates and high rates of haematological toxicity for carboplatin-based combinations, albeit with similar survival figures to patients receiving cisplatin

For The Holdovers screenwriter David Hemingson, cigarettes were an integral part of his time at an East Coast prep school in the 1970s

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The FDA did not immediately return a request for comment