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A 2021 RCT (N = 1,251) found no difference in smoking cessation rates at 52 weeks with 12-week combination varenicline plus NRT treatment versus 12-week varenicline monotherapy (or among those treated for 24 weeks)

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Around one in 20 adults in England uses e-cigarettes, and nearly all of these are ex-smokers or current smokers who are trying to cut down or quit