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Blunt use was strongly related to starting combustible tobacco (cigarettes or cigars

The target sample size was 636, based on power analysis for the primary research question using G*Power, with 90% power to determine an effect size (f2) of 0.02 on our primary outcome at an alpha level of 0.05

Dysbiosis of oral microbiota has been associated locally with periodontal, respiratory, cardiovascular and systemic cancers, including head and neck cancer [45], pancreatic cancer [46], and esophageal cancer [47], yet regarding factors that influence the oral microbiome composition are poorly understood

With the rise of large-scale cigarette manufacturing, modern storage methods have been developed to improve efficiency and quality preservation

This feature provided cigarettes an advantage over cigars, as cigar smoke is absorbed in the mouth rather than in the lungs