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B.| Under the influence of elevated glucose, RTECs undergo EMT induced by TIPE1 and the E3 ligases Parkin and RFFL

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EDS causes an imbalance between tissue breakdown and repair, the body tends toward collagen breakdown because of the genetic defect

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Furthermore, CHAC2 also maintains pluripotency through a CHAC1-independent pathway by regulating the NRF2-GCL axis, thereby sustaining GSH biosynthesis and concurrently suppressing ROS production (Wang et al., 2017)