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Chronic nicotine consumption profoundly activates macrophages via nAChRs to express pro-inflammatory cytokines, aggravating atherosclerosis and aortic lesions [279]

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This accumulation poses serious long-term health risks [9, 10]

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Not only did the researchers develop a great new in vitro model, but they were also asking themselves how closely their model was mimicking the in vivo situation, comments Carole Mathis, a cellular systems biologist at Philip Morris International