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Concerning the content of volatile organic compounds, n-heterocyclic carbenes dominated, constituting over 90% of the content in each group, primarily composed of (s)-(-)-nicotine (Fig

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In the Republic of North Macedonia, data from the Public Health Institute (PHI) published on World No Tobacco Day in 2024 shows that 45.4 percent of the countrys population are active smokers, which is significantly higher than the average in the European Union and ranks North Macedonia among the countries with the highest smoking rates in the world