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Of note, by increasing the number of portal mesenchymal cells, we generated assembloids that recapitulated several aspects of human cholestatic disease and biliary fibrosis

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Fatty acids of various lengths are metabolized to acetyl-CoA, which is used in the Krebs cycle to make ATP

Whether prolonged, systemic treatments with reductive agents that cross the blood brain barrier would prove to be an effective preventive treatment for patients at high risk remains to be established

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