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Larger sample sizes along with functional validation will be needed to further implicate these germline variants in lung cancer pathogenesis, although these early studies in individuals who have never smoked have highlighted the presence of pathogenic alterations with large effect sizes in DNA repair-related genes

ICH, Geneva Zhou CH, Yu WH, Zhao H, Tong DS, Wu LM, Yu WH (2013) Catal Rev Sci Eng 55:369453 Acknowledgments The authors gratefully acknowledge the support of the Operational Programs Research and Development for Innovations and Education for Competitiveness (CZ.1.05/2.1.00/03.0058 and CZ.1.07/2.3.00/30.0041), Grant Agency of the Czech Republic (P206/12/1150) and Palacky University in Olomouc (IGA_PrF_2014031)

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