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Research showed that ECs could renormalize and undermine tobacco control and smoking cessation efforts [26]

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However, nicotine dependence is not limited to physiological processes and can be described as an interplay between pharmacology, learned or conditioned factors, genetics, and social and environmental factors (Benowitz 2010, p

Thus, smoking is recognized as one of the most crucial factors influencing prognosis, symptom severity, and disease progression 5

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