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Symptoms Painless sores to the vagina, mouth, penis, or rectum Rash on your abdomen, palms, or bottom of your feet Wart-like bumps on genitals (goes away over time, even without treatment) Swollen lymph nodes Low-grade fever Muscle or joint pain Patchy hair loss Changes to vision or hearing How it spreads Syphilis starts as a painless sore and can spread through sexual contact during sex