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Led by the Center for the Evaluation of Nicotine in Cigarettes, the double-blind, parallel, randomized clinical trial involved 840 smokers at 10 locations who were randomly assigned to smoke for six weeks either their usual brand of cigarettes or one of six types of investigational cigarettes

Percentages of perceptions of great risk of smoking one or more packs of cigarettes per day among persons aged 12 to 17, by state: 2012 and 2013 Of the 10 states with the highest rates of adolescent perception of great risk from smoking one or more packs a day, 4 were in the Northeast (New Hampshire, Vermont, New York, and Connecticut), 3 were in the West (Colorado, California, and Utah), and 3 were in the South (Maryland, Virginia, and Florida)