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Although these pathways show that exposure to nicotine directly disrupts monoaminergic systems, disruptions of the endogenous cholinergic system, whether direct or indirect, remain a possibility

10.1158/1940-6207.CAPR-21-0567 36

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This vote required a 2/3 majority to pass and failed by a vote of 264-133

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In the face, for instance, direct exposure of the skin to smoke induces high levels of oxidative stress associated with the skin barrier disruption, whereas in the less exposed areas such as the volar forearm, the compensatory processes may maintain the barrier function