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[31] After cigarette butts are discarded, they can leach toxins including nicotine, arsenic, polycyclic aromatic hydrocarbons and heavy metals into the environment

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10.1124/jpet.112.195255

Several mechanisms work togetherreduced blood flow, oxidative stress, collagen loss, and melanin overproduction

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Many physicians still doubted that there was a wide-spread connection between smoking and disease