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TLR activation on immune and vascular cells leads to activation of downstream signaling pathways that trigger an immune response with upregulation of proinflammatory cytokines and activation of NOXs, which contribute to the development of hypertension by promoting OxS, inflammation, endothelial dysfunction, smooth muscle cell migration and proliferation, and ultimately organ damage (Hovland et al., 2015

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Journal of the American Medical Association 273(13): 1047-1053

Selling Smoke: Tobacco Advertising and Anti-Smoking Campaigns Item Enjoy smoking longer - Trapeze Title Enjoy smoking longer - Trapeze Description A cartoon trapeze artist has no partner Creator Saratoga Publisher Philip Morris Date 1976 Source Image from the William Van Duyn Tobacco Advertisement Collection (Ms Coll 20), Medical Historical Library, Harvey Cushing/John Hay Whitney Medical Library, Yale University