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To reduce the influence on our model of multiple observations coming from the same study, we adjusted the standard errors of effect sizes reported for multiple non-mutually exclusive exposure groups in each study by a factor matching the number of repeated measurements within each agesexsmoking status group (Supplementary Information Section 2.2)
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Keywords: alcohol use, tobacco use, Canada, mortality metrics, guidance on alcohol and health Introduction Alcohol use is a causal risk factor for over 230 disease conditions based on the three-digit International Classification of Diseases, Revision 10 (ICD-10) codes (1)
Both Healton and Dobbins signed the letter attached to the 2015 literature review, which was sent to the FDA, as well as several other documents and testimony presented at FDA hearings on what the best science reflected at the time
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