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It weakens the immune system, and it becomes harder to fight off infections and diseases

2004, Atlanta, GA: US Department of Health and Human Services, Centers for Disease Control and Prevention, National Center for Chronic Disease Prevention and Health Promotion, Office on Smoking and Health World Health Organization (WHO): WHO Framework Convention on Tobacco Control

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In fact, a Reddit user created a fascinating chart of all of DiCaprio's supposed girlfriends

Given that studies have failed to find an association between CYP2D6 polymorphism and incidence of depression (178), the most likely conclusion is the latter, in which individuals have an increased need to try different therapeutics in search of a positive therapeutic response (176, 177)