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355,356 The abundant lipids and membrane-bound proteins on the surface of exosomes provide binding sites for targeting ligands, such as peptides, antibodies, and aptamers

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Additionally, pro-apoptotic proteins can be activated and anti-apoptotic proteins can be suppressed by calcitriol/VDR signaling, which may also reduce tumor-associated inflammation by suppressing the cyclooxygenase-2, prostaglandin, and NF-kB pathways