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This year, her Astoria, Ore.-based company was overwhelmed by orders from tobacco users slammed by "the market collapse, the recession, then getting hit with exorbitant tobacco taxes." Moore doesn't use tobacco herself but has no misgivings about her business

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This correlation has driven research into nicotines effects on dopaminergic pathways and inflammatory processes that contribute to neuronal loss in the substantia nigra

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The bottom line is, the program was not working, Snell said