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The patient also had a history of infective endocarditis, which had required placement of a mechanical mitral valve one of the few remaining indications for which warfarin is the firstline therapy (there are fewer data for novel anticoagulants)

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Heart Circ Physiol 294, H272135.CrossRefGoogle ScholarPubMed Gialitakis, M, Tolaini, M, Li, Y, Pardo, M, Yu, L, Toribio, A, Choudhary, JS, Niakan, K, Papayannopoulos, V and Stockinger, B (2017)