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Matias WR, Bourque DL, Niwano T, Onderdonk AB, Katz JT

Santiago is one of the largest tobacco growing regions in the world

Given the importance of biofilm formation for adhesion in the oral cavity [70], and the fact that cigarette smoke increased biofilm formation by specific bacteria and promoted colonization [34], it would be reasonable to suspect that oral microbiome might be the missed connectivity between smoking and infective endocarditis

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1996 Researchers find conclusive evidence that tobacco damages a cancer-suppressor gene