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Mechanistically, low CFTR expression impairs the expression of the chloride ion-sensitive with-no-lysine kinase 1 (WNK1) protein, thereby leading to activation of transient receptor potential cation vanilloid 4 (TRPV4)

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It protected the gut lining from corrosive agents like NSAIDs (non-steroidal anti-inflammatory drugs) that normally cause bleeding and ulcers

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