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Like the rest of the chemicals, the liver metabolizes nicotine through the enzymes CYP2A6, FMO, and UGT

In general, the total production indicated a notable increase from 2013 to 2024: its value increased at an average annual rate of +2.3% over the last eleven-year period

The latest update concluded that there was highcertainty evidence that e-cigarettes with nicotine increase quit rates compared with NRT and moderatecertainty evidence that they increase quit rates compared with e-cigarettes without nicotine

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This raises the level of nicotine in the bloodstream