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Also, because GLP-1 drugs engage the brain's reward circuitry the same system that governs not just craving but everyday motivation prolonged use could, in theory, dampen motivational drive in some people

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The hardening hypothesis proposes that as the prevalence of smoking in a population declines, a greater proportion of the remaining smokers will have less motivation to quit, be more dependent on smoking, will make fewer quit attempts and will be less likely to quit

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