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Certain Medications Drugs like antimalarials, antibiotics, and chemotherapy agents can lead to lip darkening

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Impossible to enforce: Big Tobacco exploiting loopholes in European menthol ban Getting your Trinity Audio player ready

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Additionally, the nicotine gum can irritate the mouth, which may cause stomatitis, Gingivitis, aphthous ulcers, glossitis and a change in the persons salivary flow and taste buds

and nicotine which is commonly used as an insecticide