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While after treating with various flavoring compounds, the endothelial cells of the subjects decreased the production of nitric oxide and induced inflammation consistent with endothelial dysfunction [48]

However, 18 (26.9%) of the 67 IBS(+) smokers reported a decrease in GI symptoms, such as abdominal bloating, constipation, and diarrhea, in the first year after smoking cessation (Figure 3)

The growth of smokeless products worries some public health advocates who think the new products appeal to children