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Similar increases in the red cell indices have been observed with significantly larger values of MCV and MCH among smokers, while differences in values of MCHC were not significant between smokers and non-smokers 13

In the most extreme case, comparing an average non-smoker to a worst-case smoker yields gaps of ~ 6.4 years (males) and ~ 8.8 years (females), whereas comparing to a best-case (low-risk) smoker yields a much smaller gap (~ 2.0 years for males)

The inhalation of nicotine induces higher levels of this substance compared with subcutaneously administration

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