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HIFs are protective in the short-term, but chronic HIF stabilization in the RPE can exert detrimental effects [15,16,17,18], from which the metabolic shift is most relevant for the present study

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The majority of the studies used a casecontrol design ( n = 235), followed by prospective cohort ( n = 156), nested casecontrol ( n = 10), retrospective cohort ( n = 5), casecohort ( n = 3) and case-crossover ( n = 1) designs