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Health Minister Saira Afzal Tarar announced the increase in February this year to raise awareness of cancers and other serious illnesses related to cigarette smoking

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Metabolic mold microorganism activities can decompose or transform alkaloids, decreasing the total alkaloid content in tobacco leaves

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It may occur without cause, or it may be triggered by: Alcohol withdrawal Emotional stress Exposure to cold Medicines that cause narrowing of the blood vessels (vasoconstriction) Stimulant drugs, such as amphetamines and cocaine Cocaine use and cigarette smoking can cause severe spasms of the arteries