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We anticipate that future diagnostic classifications for IC/BPS are likely to include this categorization

Additionally, at least part of central ghrelins effects can be mediated by GH/IGF-1, as ghrelin stimulates systemic GH secretion and local GH expression in various brain regions

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doi: 10.1136/gutjnl-2015-309990 46 MiyakeS.KimS.SudaW.OshimaK.NakamuraM.MatsuokaT.et al

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The logic is straightforward: with less food and digestive action in the stomach, the peptide has a clearer and faster path to the intestines where it can exert its effects directly on the gut lining with minimal interference