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It also reprograms MCs transcriptional profiles from an activated to a quiescent state (158) and reduces vascular permeability in humanized mouse models (157), suggesting both anti-inflammatory and barrier-protective effects relevant to AD

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The study also noted that adverse effects such as nausea, vomiting, abdominal pain, and drowsiness were reported more frequently by men, which may further support the notion of more intense or unregulated use patterns