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A beta carotene and retinol efficacy trial (CARET) consisting of approximately 60% current smokers and 39% ex-smokers (total of 18,314 male and female subjects) exposed to asbestos, was conducted for 4 years to evaluate the therapeutic efficacy of either retinol (25,000 IU/day) plus -carotene (30 mg/day) or placebo [79]

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