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The stimulation of nAChRs by nicotine also likely affects downstream signaling molecules, including protein kinases, which are important regulators of synaptic plasticity and memory (37)

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This may be because: Nicotine affects neurotransmitters (chemical messengers) in the brain, increasing the release of happy hormones such as dopamine and serotonin

Figure 3 Figure 4 shows the trends in the tobacco-attributable age-standardized DALY rates per 100,000 people from 1990 to 2017